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desvenlafaxine will boost the degree or influence of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, four hundred mg) decrease the CYP2D6 substrate dose by as many as fifty%; no dosage adjustment required with desvenlafaxine doses seven consecutive tim